8-Oxo-2'-Deoxyguanosine - Biomarker, Signal Molecule, Potential Pharmaceutical Agent

8-Oxo-7,8-dihydro-2'-deoxyguanosine Forms a Relatively Unstable Tetrameric Structure Compared with 2'-Deoxyguanosine

The hydrogen-bonded guanine tetrad, or G-quartet has been implicated in a variety of biological roles, including the function of chromosome telomeres. Here effect of the hydroxylation of guanosine at the 8 position on the G-quartet formation was examined. Electrospray inonization mass (ESI-MS) spectra of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 2'-deoxyguanosine (dG) were measured in o...

G quadruplexes stabilised by 8-oxo-2'-deoxyguanosine.

G quadruplexes (GQPs) are four-stranded secondary structures formed of guanosine-rich nucleic acids. They consist of at least two G tetrads composed of four guanosine nucleotides. DNA GQPs have been shown to fold into a variety of different topologies that can be divided into antiparallel and parallel conformations (the latter is depicted in Figure 1 A).[!] The topology of DNA GQPs depends on t...

8 - Oxo - 7 , 8 - dihydro - 2 ’ - deoxyguanosine : Reduce , Re - use , Recycle ?

Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.

Of the DNA-derived biomarkers of oxidative stress, urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most frequently measured. However, there is significant discrepancy between chromatographic and immunoassay approaches, and intratechnique agreement among all available chromatography-based assays and ELISAs is yet to be established. This is a significant obstacle to their use in larg...

Assessing Free-Radical-Mediated DNA Damage during Cardiac Surgery: 8-Oxo-7,8-dihydro-2′-deoxyguanosine as a Putative Biomarker

Coronary artery bypass grafting (CABG), one of the most common cardiac surgical procedures, is characterized by a burst of oxidative stress. 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), produced following DNA repairing, is used as an indicator of oxidative DNA damage in humans. The effect of CABG on oxidative-induced DNA damage, evaluated through the measurement of urinary 8-oxodG by a develo...